Phone:(095)925-74-48, (095)923-36-02

Fax: (095)923-36-02

Email: [email protected]

Bank account: N 608112 in MACB "Vozrozhdenie", Pushchino

DATE OF FOUNDATION: July 1, 1965

MAIN RESEARCH DIRECTIONS

• biochemistry and physiology of microorganisms, including symbionts and plants parasites;

• microbial metabolism and its' regulation

• molecular biology and molecular genetics

• environment protection biotechnology: new technologies development and improvement of those already in use based on cultivating of clear microorganisms cultures, including strains obtained by means of gene- tical engineering; usage of natural assotiations of microorganisms and microbial preparations for water, soil, industrial and non-industrial drains cleaning and solid waste products convertion.

• formation and support of All-Russia collection of microorganisms cultures; isolation, phisiological and morpho-cytological studing of new microorganisms forms, the culture collection enrichment.

• development of methods for mass cultivating of different microor- ganisms physiological groups, including strains obtained by means of genetical engineering.

  INSTITUTE STRUCTURE

  1. Section "ALL-RUSSIA MICROORGANISMS COLLECTION" (Assoc. member RAS, Prof. L.V.Kalakutskii)
     • Laboratory of structure-functional adaptation of microorganisms. (D.Sc in Biology., Prof. V.I.Duda)

  2. SECTION OF CELLULAR SUFACE BIOCHEMISTRY (Assoc. member RAS, Prof.I.S. Kulaev)
     • Laboratory of biochemical processes regulation (Assoc. member RAS, Prof.I.S. Kulaev)

     • Temporary sientific group "Biochemistry of secretion processes in bacteria" (D.Sc in Biology., Prof. M.A. Nesmeyanova)

  3. SECTION OF MOLECULAR GENETICS (Assoc. member RAS, Prof.A.M.Boronin)
     • Laboratory of plasmids biology (Assoc. member RAS, Prof.A.M.Boronin)

     • Laboratory of gene sistematics (C.Sc in Biology N.P.Kuzmin)

     • Laboratory of structure-functional analysis of genetical systems of microorganisms (C.Sc in Biology V.N.Ksenzenko)

  4. SECTION OF MOLECULAR BIOLOGY (D.Sc in Biology. V.I.Taniashin)
     • Laboratory of genetical enzymology (D.Sc in Biology. V.I.Taniashin)

     • Laboratory of mobile genetic elements (D.Sc in Biology V.A. Ivanov)

  5. SECTION OF FERMENTATION MICROBIOLOGY (D.Sc in Biology, Prof. V.K.Eroshin)
     • Laboratory of enzymatic degradation of organic compounds (D.Sc in Biology, Prof. L.A. Golovleva)

     • Laboratory of microbiological transformation of organic compounds (D.Sc in Biology, Prof. K.A. Koshcheenko)

     • Laboratory of anaerobic processes (D.Sc in Biology, Prof. V.K Akimenko)

     • Laboratory of ecological physiology of microorganisms (D.Sc in Biology, Prof. E.L.Golovlev)

     • Laboratory of oxidative metabolism (D.Sc in Biology, Prof. T.V.Finogenova)

     • Laboratory of unnatural compounds metabolism (C.Sc in Biology I.I.Starovoitov)

     • Laboratory of radioactive compounds (D.Sc in Biology, Prof. Iu.A.Trotsenko)

     • Laboratory of mass-spectrometric monitoring (D.Sc in Biology A.M. Ziakun)

     • Temporary scientific group "Biosensors" (C.Sc. in Physical and Mathematical Sciences A.N.Reshetiov)

     • Temporary scientific group "Biochemistry of membranous structures) (C.Sc in Biology A.S.Solonin)

     • Temporary sientific group " Enzymes for genetical engineering" (C.Sc in Biology A.S.Solonin)

     • Center for instrumental analysis methods (M.U.Arinbasarov)

     • Center for computer equipment (S.V.Lyssakov)

     • Laboratory of biotechnological processes (C.Sc in Biology V.A.Samoilenko)

     • Laboratory of microorganisms cultivation (G.G.Panteleeva)

     • Laboratory of nutritious media (N.I.Santsevich)

     • Engineering-technical center

     • Patent center (L.G.Belyakova)

     • Center for international scientific-technical collaboration (L.V.Tsvetnitskii)

     • Scientific-organizing group (D.Sc in Biology T.A.Reshetilova)

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  The Institute is a member of the Russian-American Consortium for techological, educational and economical development. The participants from the American side are Washington (Pullman) and California (Berke- ley and Riverside) State Universities. The purpose of the Consortium is to work under the project "Integration of Science and education and technology transfer for sustainable economic development and envi- ronment protection of the South-Central region of the European Rus- sia".

  THE MAIN SCIENTIFIC AND APPLIED ACHIEVEMENTS OF THE INSTITUTE DURING LAST 10 YEARS

  There has been created and is supported and enriched the biggest collection of actinomycetes, bacteria, archebacteria, yeast and micelial fungi, and genetically modified microorganisms in Russia. Guides and Catalogues of microorganisms are created and published.

  Created are Collection funds and working collections of microorganisms:

  • destructors of alien compounds: polychlorided aromatic pollutants, S- and P- containing pesticides, oil, oil-products and poliaromatic compounds

  • producers of antibiotics, polysaccharides, alkaloides and micotoxines.

  • straines of extremofils, including inhabitants of ruminant animal's tripe and producers of base-tolerant cellulases.

  • methylotrophic bacteria and yeast

  • PGDR Pseudomonas, having a range of characteristics useful in biotechnology

  • fruit putrefaction inhibitors

  On the basis of studies of oxidative and energetic metabolism of yeast there was created a conception about biochemical mechanism of overproduction of some metabolites. The results provided the basis for development of new technologies of producing valuable metabolites (citric,iso-citric and other acids) and enzymes (alcoholdehydrogenase, alcoholoxidase, etc.)

  A theory explaining material-energetic balance of microbial biosynthesis products accumulation and producers' growth was created, which has fundamental significance and is the basis for technological calculation of biosynthesis processes. Biochemical characteristics of these processes, recommended by IUPAC, are introduced for use in microbiology. For the first time the conception of zone of double limit of growth of microorganisms is formulated.

  A new mechanism for removal of detoxificated tellure forms from cells is found; peculiarities of structure-functional organization of cells of Pseudomonas genus tolerant to high concentrations of heavy metals. The results are providing basis for development of biotechnical technology for the metals removing from environment.

  The work on obtaining a complete collection of cloned genes of amber-supressor tRNA of T5 bacteriophage is finished. The collection obtained is used for works in protein engineering for rapid check of influence of directed aminoacid substitutions on the functional activity of proteins when studying biogenesis and secretion of base phosphotase of E.coli.

  For the first time there has been found a major structure and metabolism difference between polyphosphates in different organells (nucleus, vakuole,cell membrane, cytozole) of cells of eucariotic organisms. Pecularities of poliphosphate metabolism in one or another organelle are closely connected with its main function.

  There has been created cientific and technological base for directed construction of microbial associations (including granulated consortiums of anaerobic bacteria) with programmed characteristics for development of effective technologies for environment cleaning (cleaning facilities, industrial production, places polluted by oil-products).

  Unique methods and preparations are created and also experimental-industrial technologies for their production are developed to solve practical problems of ecology and medicine:

  • "Immunophit"," Avermectin", "Pseudobacterin" preparates - natural, ecologically harmless means for protection of plants from various diseases.

  • "Lisoamidase" - a uniqe preparation, which is based on a polisaccharide-enzyme complex, performing hydrolisis of cell wall of Gram-positive bacteria.

  • biosensors - new methods and preparations on the basis of immobilized microorganisms cells for detection of toxic compounds, carbohydrates, alcohols; a universal model of immunosensor is created, adapted for a broad spectrum of analized objects -from low-molecular weight compounds to whole cells.